Osteoarthritis Medications
Supplements are used to enhance the efficacy of therapeutic medications. Herbal remedies or vitamin capsules are examples. For conditions such as OA where the disease can be managed by enhancing bone and cartilage health, the doctor prescribes supplements in addition to the other medications. Prescription-only supplements are preferable. The physician is better able to determine the option, dosage, and potential adverse effects. These are some of the most common:
The amino sugar Glucosamine
In the human body, Glucosamine is synthesized as a chemical component of the majority of proteins that conjugate with carbohydrates to form glycoproteins, which comprise bone, synovium cartilage, and other connective tissues. It has anti-inflammatory properties and is beneficial to normal joint structure health.
Both Glucosamine sulfate and Glucosamine hydrochloride are utilized. Glucosamine sulfate has been the subject of more research and has demonstrated superior efficacy compared to the other formula. The source of exogenous Glucosamine is the exoskeleton of seashells. However, it is considered harmless for individuals with shellfish allergies. In the majority of OA patients, Glucosamine reduced pain and slowed the rate of disease progression. Nevertheless, some investigations demonstrate no significant improvement. The distinction may be attributable to distinct formulations, dosages, etc.
The compound chondroitin
It is another glycosaminoglycan component that creates the joint matrix. Despite being a direct structural component of the joints, studies on the efficacy of chondroitin in osteoarthritis have not yielded encouraging results. When combined with other medications and supplements, such as aspirin for pain alleviation and Glucosamine supplements for joint structure, it has been shown to alleviate pain and even prevent joint space narrowing. However, additional research is necessary before recommending chondroitin as a supplement.
The amino acid S-adenosylmethionine
This liver-derived substance is inherently cartilage-enhancing. It stimulates chondrocyte proliferation, reversing the cartilage thinning caused by OA. Additionally, it protects cartilage against cytokine-mediated injury.
Studies on the effects of S-AMe have produced encouraging findings. It has been observed to reduce pain and is well tolerated by the vast majority of OA patients. Nevertheless, it takes time for the symptoms to subside.
The price is a significant disadvantage of using this supplement. Aside from this, it can disrupt sleep, induce headaches and agitation, and interact with other medications. This decreases its suitability for regular use.
D vitamin
Vitamin D plays an active role in supporting bone health. Due to immobilization, the OA-affected elderly population is also at risk for osteoporosis and fractures. It is suggested that 400 IU of vitamin D be consumed one to three times per week. Vitamin D supplementation has been shown to reduce cartilage degeneration in a four-year study. It reduces discomfort and enhances functionality. Combining vitamin C and vitamin D has proven to be more beneficial. In measured amounts, it is harmless for consumption.
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