Blood loss
Anemia is a prevalent manifestation of hemolytic uremic syndrome in children and is associated with a poorer prognosis. In hemolytic uremic syndrome, bacteria in the digestive tract break down hemoglobin from red blood cells into byproducts that damage the kidneys and cause anemia.
Hemolytic uremic syndrome can cause normocytic or hypochromic anemia. In hemolytic uremic syndrome, both red cell destruction and decreased erythropoiesis contribute to the anemia, as indicated by the low serum iron level, low total iron-binding capacity, high serum soluble transferrin receptor level, and decrease in the percentage of serum lactate dehydrogenase (LDH) released into plasma.
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