Vitamin B12 Shortage
Some individuals may experience vitamin B12 deficiency, which can result in neurological and hematologic symptoms. Vitamin B12 is abundant in the liver, which diminishes the likelihood of its deficiency. In some cases, vitamin B12 is not absorbed in the intestine, possibly due to dietary deficiencies, a lack of intrinsic factor, or malabsorption. In addition, other health conditions, such as hepatic ulcer depletion and other deficiencies, can cause vitamin B12 deficiency.
The prevalence of vitamin B12 deficiency varies significantly between individuals based on their underlying causes. Some studies indicate that approximately 1% to 2% of anemia cases in the general population are attributable to vitamin B12 deficiency. Other studies indicate that between 18 and 20 percent of individuals with clinical macrocytosis were deficient in vitamin B12. Regardless of the underlying cause, vitamin B12 deficiency is more common in the elderly. Pernicious anemia resulting in vitamin B12 deficiency is more prevalent among individuals of Northern European descent than those of African descent.