Performing biopsies
To evaluate the prognosis of ongoing treatment, microbiopsies of the affected area are performed. A biopsy is an invasive procedure that permits in-depth histological analysis of individual cases. This makes it a valuable instrument for evaluating the efficacy of new research treatment designs and customising patient care.
The progression of the condition can be evaluated using the following metrics created to grade cellulite. The Nurnberger-Muller scale is the earliest and most straightforward method based on pressure test results.
Grade 0: Resting or contracted, there are no dimples, but squeezing reveals a “orange peel” appearance.
Grade 1: Visible “orange peel” when upright, but not when lying down.
Grade 2: Visible “orange peel” both when standing and when lying down.
For improved evaluation, more comprehensive and intricate grading scales are created. This includes the Rosi and Vergnanini scale, which considers critical histology, the CSS developed by Hexsel et al, which also takes into consideration skin elasticity, number, and depth of depressions, and the Nurnberger-Muller scale.
