Chronic Tophaceous Gout
The accumulation of uric acid in the blood over time can result in the widespread formation of tophi (a crystalline uric acid deposit) in and around joint spaces and beneath the epidermis. The accumulation of these brittle, irregular crystals can erode cartilage and bone, leading to the onset of chronic arthritis symptoms.
Chronic arthritis is characterised by persistent inflammation and pain along with a general sensation of malaise, fatigue, and anaemia, in contrast to acute attacks of gout. Over time, the joint can become rigid and begin to impede mobility and movement.
The majority of tophi develop in the great toe, at the tip of the elbow, and around the digits. However, they can manifest almost anywhere on the body. In rare instances, tophi can penetrate the skin and produce nodules resembling chalk. Additionally, they have been observed along the spine, in the nostrils, and even on the vocal cords. The vast majority of tophi are considered innocuous unless they grow larger or begin to impair joint mobility.
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