Signs and Symptoms Of Gout
Typical gout symptoms appear suddenly and without warning. It commonly affects the large joints of the foot, such as the metatarsophalangeal joint of the great toe, and the knee, but it can also affect the ankles, elbows, fingertips, and wrists. It typically progresses through various stages, and consequently, its signs and symptoms manifest differently at each stage. These consist of:
Hyperuricemia with no symptoms
Although nearly all patients with gout have elevated blood uric acid levels (hyperuricemia), not all patients with hyperuricemia develop gout. Prior to experiencing their first gout attack, the majority of patients will have had elevated uric acid levels in their blood for many years. However, there are no definitive guidelines for treatment during this time, particularly in the absence of gout symptoms. This stage of gout in which there is active uric acid in the blood but no clinical symptoms is known as asymptomatic hyperuricemia.
The likelihood of an acute gout attack increases as uric acid levels rise. Intriguingly, however, many patients can experience attacks with “normal” levels of uric acid, while others will never experience an attack despite having elevated uric acid levels. This is due to genetic predisposition and additional socioenvironmental factors.
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